Spatial dimension directly impacts the research of geographical objects distribution. This paper uses grid, spatial autocorrelation and Gini coefficient to study the spatial distribution features of Liaoning's manufacturing with results showing that Shenyang and Dalian are two core cities for holding manufacturing with lower production in the west and east of Liaoning province. The surrounding areas of major city centers are the hubs of manufacturing. As research spatial dimension increases, multiple-center pattern of Liaoning's manufacturing distribution turns into two-core pattern of Dalian and Shenyang, with other cities displaying manufacturing centers only under the scale of 10-15 km. The spatial difference and spatial correlation show scale effect with 6-54 km as an appropriate scale in studying the spatial concentration of Liaoning's manufacturing, under which Liaoning's manufacturing shows a large spatial difference and spatial correlation.